Drug interactions
Telavancin + Tenofovir df
Severity: Major
Telavancin and Tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can harm the kidneys, and telavancin carries a boxed warning for nephrotoxicity. Using them together may increase the risk of acute kidney injury and could raise tenofovir exposure if renal function falls.
What this interaction means in plain words
Telavancin and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of tenofovir when kidney function declines.
What to do
Monitor serum creatinine and creatinine clearance at baseline and frequently during therapy. Adjust doses to renal function or choose alternatives such as tenofovir alafenamide or a non-nephrotoxic antibiotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Telavancin with Tenofovir df?
MediHelp rates the interaction as major. Telavancin and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can harm the kidneys, and telavancin carries a boxed warning for nephrotoxicity. Using them together may increase the risk of acute kidney injury and could raise tenofovir exposure if renal function falls.
How serious is the interaction between Telavancin and Tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and creatinine clearance at baseline and frequently during therapy. Adjust doses to renal function or choose alternatives such as tenofovir alafenamide or a non-nephrotoxic antibiotic.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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