Drug interactions
Telavancin + Tenofovir disoproxil
Severity: Major
Telavancin and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telavancin carries a risk of acute kidney injury, and tenofovir can cause proximal tubular toxicity. Concurrent use may increase renal injury risk and raise tenofovir exposure.
What this interaction means in plain words
Telavancin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity with reduced renal clearance of tenofovir.
What to do
Avoid the combination where an alternative antibiotic exists. If it is needed, monitor serum creatinine daily or frequently and adjust tenofovir dosing to creatinine clearance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Telavancin with Tenofovir disoproxil?
MediHelp rates the interaction as major. Telavancin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Telavancin carries a risk of acute kidney injury, and tenofovir can cause proximal tubular toxicity. Concurrent use may increase renal injury risk and raise tenofovir exposure.
How serious is the interaction between Telavancin and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic exists. If it is needed, monitor serum creatinine daily or frequently and adjust tenofovir dosing to creatinine clearance.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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