Drug interactions
Telavancin + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Telavancin and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telavancin can prolong the QTc interval, and vilanterol, a long-acting beta-agonist, may add to this and cause tachycardia and hypokalemia. Systemic exposure from the inhaled product is low, so the clinical effect is usually modest, but it may matter in patients with cardiac risk factors.
What this interaction means in plain words
Telavancin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and beta-adrenergic cardiovascular stimulation.
What to do
Check a baseline ECG and potassium in patients with cardiac risk factors and monitor for palpitations or arrhythmia during telavancin therapy. Consider an alternative antibacterial in patients with known long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Telavancin with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Telavancin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telavancin can prolong the QTc interval, and vilanterol, a long-acting beta-agonist, may add to this and cause tachycardia and hypokalemia. Systemic exposure from the inhaled product is low, so the clinical effect is usually modest, but it may matter in patients with cardiac risk factors.
How serious is the interaction between Telavancin and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and potassium in patients with cardiac risk factors and monitor for palpitations or arrhythmia during telavancin therapy. Consider an alternative antibacterial in patients with known long QT syndrome.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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