Drug interactions
Temocillin + Tetracycline
Severity: Moderate
Temocillin and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracycline may theoretically reduce the bactericidal activity of temocillin, a beta-lactam that requires actively dividing bacteria. Clinical evidence is lacking.
What this interaction means in plain words
Temocillin and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between a bacteriostatic agent and a growth-dependent bactericidal beta-lactam.
What to do
Avoid concurrent use where an alternative exists. If both are needed in serious infection, monitor clinical response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Temocillin with Tetracycline?
MediHelp rates the interaction as moderate. Temocillin and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracycline may theoretically reduce the bactericidal activity of temocillin, a beta-lactam that requires actively dividing bacteria. Clinical evidence is lacking.
How serious is the interaction between Temocillin and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If both are needed in serious infection, monitor clinical response closely.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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