Drug interactions
Tenofovir df + Tobramycin
Severity: Moderate
Tenofovir df and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and impaired renal function may increase exposure to tenofovir and tobramycin. The combination raises the risk of acute kidney injury and ototoxicity.
What this interaction means in plain words
Tenofovir df and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with reduced renal elimination of both drugs when kidney function declines.
What to do
Monitor serum creatinine, phosphate and tobramycin levels during combined use. Consider an alternative antibiotic or antiretroviral regimen in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Tenofovir df with Tobramycin?
MediHelp rates the interaction as moderate. Tenofovir df and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and impaired renal function may increase exposure to tenofovir and tobramycin. The combination raises the risk of acute kidney injury and ototoxicity.
How serious is the interaction between Tenofovir df and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and tobramycin levels during combined use. Consider an alternative antibiotic or antiretroviral regimen in patients with renal impairment.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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