Drug interactions
Tenofovir df + Tolmetin
Severity: Moderate
Tenofovir df and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion, and NSAIDs can lower renal perfusion. Together they may increase the risk of tenofovir-associated kidney injury, especially with high or multiple NSAID doses.
What this interaction means in plain words
Tenofovir df and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in renal blood flow and shared renal elimination raise tenofovir exposure and nephrotoxicity risk.
What to do
Use paracetamol or another alternative where feasible. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Tenofovir df with Tolmetin?
MediHelp rates the interaction as moderate. Tenofovir df and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by glomerular filtration and tubular secretion, and NSAIDs can lower renal perfusion. Together they may increase the risk of tenofovir-associated kidney injury, especially with high or multiple NSAID doses.
How serious is the interaction between Tenofovir df and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use paracetamol or another alternative where feasible. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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