Drug interactions
Tenofovir df + Trospium
Severity: Moderate
Tenofovir df and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo renal elimination including active tubular secretion, so they may compete and raise each other's concentrations. The clinical effect is probably small in patients with normal renal function but may matter when kidney function is reduced.
What this interaction means in plain words
Tenofovir df and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for renal tubular secretion transporters reducing clearance of both drugs.
What to do
Monitor renal function and for adverse effects of both drugs, particularly in renal impairment, and adjust doses to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Frequently asked questions
Can I take Tenofovir df with Trospium?
MediHelp rates the interaction as moderate. Tenofovir df and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs undergo renal elimination including active tubular secretion, so they may compete and raise each other's concentrations. The clinical effect is probably small in patients with normal renal function but may matter when kidney function is reduced.
How serious is the interaction between Tenofovir df and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for adverse effects of both drugs, particularly in renal impairment, and adjust doses to creatinine clearance.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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