Drug interactions
Tenofovir df + Valganciclovir
Severity: Moderate
Tenofovir df and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ganciclovir and tenofovir are cleared renally and can contribute to kidney injury. Combined use may raise exposure to either drug and increase risk of renal toxicity or myelosuppression, especially with impaired renal function.
What this interaction means in plain words
Tenofovir df and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and additive nephrotoxic potential.
What to do
Monitor serum creatinine, phosphate and blood counts, and adjust doses to creatinine clearance. Consider alternatives if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tenofovir df and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Valganciclovir
Frequently asked questions
Can I take Tenofovir df with Valganciclovir?
MediHelp rates the interaction as moderate. Tenofovir df and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ganciclovir and tenofovir are cleared renally and can contribute to kidney injury. Combined use may raise exposure to either drug and increase risk of renal toxicity or myelosuppression, especially with impaired renal function.
How serious is the interaction between Tenofovir df and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and blood counts, and adjust doses to creatinine clearance. Consider alternatives if renal function worsens.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
