Drug interactions
Tenofovir disoproxil + Tolmetin
Severity: Moderate
Tenofovir disoproxil and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin can reduce renal perfusion and, with tenofovir's tubular toxicity, may raise the risk of kidney injury. Risk is higher with repeated or high NSAID dosing and in patients with reduced renal reserve.
What this interaction means in plain words
Tenofovir disoproxil and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID-induced prostaglandin inhibition and tenofovir proximal tubular injury.
What to do
Use a non-NSAID analgesic when possible. If an NSAID is required, keep the dose low and short and monitor creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Tenofovir disoproxil with Tolmetin?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin can reduce renal perfusion and, with tenofovir's tubular toxicity, may raise the risk of kidney injury. Risk is higher with repeated or high NSAID dosing and in patients with reduced renal reserve.
How serious is the interaction between Tenofovir disoproxil and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-NSAID analgesic when possible. If an NSAID is required, keep the dose low and short and monitor creatinine and phosphate.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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