Drug interactions
Tenofovir disoproxil + Ublituximab
Severity: Minor
Tenofovir disoproxil and Ublituximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and increases infection risk. A pharmacokinetic interaction with tenofovir is not expected, but in patients with hepatitis B ublituximab can cause HBV reactivation, which tenofovir may be used to prevent.
What this interaction means in plain words
Tenofovir disoproxil and Ublituximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No direct pharmacokinetic or pharmacodynamic interaction; immunosuppression from ublituximab is the relevant concern.
What to do
Screen for hepatitis B before ublituximab and continue antiviral therapy as indicated, monitoring for infections.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ublituximab
Frequently asked questions
Can I take Tenofovir disoproxil with Ublituximab?
MediHelp rates the interaction as minor. Tenofovir disoproxil and Ublituximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ublituximab depletes B cells and increases infection risk. A pharmacokinetic interaction with tenofovir is not expected, but in patients with hepatitis B ublituximab can cause HBV reactivation, which tenofovir may be used to prevent.
How serious is the interaction between Tenofovir disoproxil and Ublituximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for hepatitis B before ublituximab and continue antiviral therapy as indicated, monitoring for infections.
What other medicines interact with Ublituximab?
MediHelp also lists interactions of Ublituximab with, for example, Azathioprine, Baricitinib, Cyclosporin. The full list is on the Ublituximab page.
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