Drug interactions
Tenofovir disoproxil + Valganciclovir
Severity: Moderate
Tenofovir disoproxil and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir, the active form of valganciclovir, and tenofovir are both cleared by the kidney with active tubular secretion. Competition may raise levels of either drug, and both may affect renal function.
What this interaction means in plain words
Tenofovir disoproxil and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and additive renal burden.
What to do
Monitor serum creatinine and blood counts, and adjust doses to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valganciclovir
Frequently asked questions
Can I take Tenofovir disoproxil with Valganciclovir?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganciclovir, the active form of valganciclovir, and tenofovir are both cleared by the kidney with active tubular secretion. Competition may raise levels of either drug, and both may affect renal function.
How serious is the interaction between Tenofovir disoproxil and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and blood counts, and adjust doses to creatinine clearance.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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