Drug interactions
Terazosin + Yohimbe
Severity: Moderate
Terazosin and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe (yohimbine) is an alpha-2 antagonist that increases sympathetic activity and can counteract the effect of terazosin. Blood pressure may become labile, with possible hypertension, tachycardia or palpitations.
What this interaction means in plain words
Terazosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Yohimbine's alpha-2 antagonism increases noradrenaline release and opposes alpha-1 blockade, with unpredictable hemodynamic effects.
What to do
Advise patients to avoid yohimbe products while on terazosin. If used, monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Terazosin with Yohimbe?
MediHelp rates the interaction as moderate. Terazosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe (yohimbine) is an alpha-2 antagonist that increases sympathetic activity and can counteract the effect of terazosin. Blood pressure may become labile, with possible hypertension, tachycardia or palpitations.
How serious is the interaction between Terazosin and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products while on terazosin. If used, monitor blood pressure and heart rate.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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