Drug interactions
Terazosin + Zotepine
Severity: Moderate
Terazosin and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-1 adrenergic blocking activity, so combining it with terazosin can add to blood pressure lowering. This may cause orthostatic hypotension, dizziness and falls, especially when starting treatment or raising doses.
What this interaction means in plain words
Terazosin and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive alpha-1 adrenergic receptor blockade producing vasodilation.
What to do
Monitor standing and sitting blood pressure when starting or titrating either drug, and advise patients to rise slowly. Start with low doses and reduce terazosin if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Terazosin and Zotepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Terazosin with Zotepine?
MediHelp rates the interaction as moderate. Terazosin and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-1 adrenergic blocking activity, so combining it with terazosin can add to blood pressure lowering. This may cause orthostatic hypotension, dizziness and falls, especially when starting treatment or raising doses.
How serious is the interaction between Terazosin and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure when starting or titrating either drug, and advise patients to rise slowly. Start with low doses and reduce terazosin if symptomatic hypotension occurs.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
