Drug interactions
Tetracycline + Tofacitinib
Severity: Minor
Tetracycline and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline is not a clinically relevant CYP3A4 or CYP2C19 inhibitor, so no meaningful change in tofacitinib exposure is expected. The interaction is theoretical.
What this interaction means in plain words
Tetracycline and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tetracycline belongs to Anti Bacterial; Tofacitinib belongs to Musculoskeletal.
Why it happens
No established mechanism; any CYP3A4 inhibition by tetracycline is negligible.
What to do
No dose adjustment is required. Routine monitoring for tofacitinib adverse effects is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Tetracycline with Tofacitinib?
MediHelp rates the interaction as minor. Tetracycline and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline is not a clinically relevant CYP3A4 or CYP2C19 inhibitor, so no meaningful change in tofacitinib exposure is expected. The interaction is theoretical.
How serious is the interaction between Tetracycline and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Routine monitoring for tofacitinib adverse effects is sufficient.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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