Drug interactions
Thioguanine + Trastuzumab
Severity: Moderate
Thioguanine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Thioguanine adds marrow suppression, so infection risk may rise.
What this interaction means in plain words
Thioguanine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thioguanine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression; the contribution of trastuzumab is not fully characterized.
What to do
Monitor blood counts regularly and evaluate fever promptly. Reduce the thioguanine dose or delay treatment if significant neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioguanine
Other interactions of Trastuzumab
Frequently asked questions
Can I take Thioguanine with Trastuzumab?
MediHelp rates the interaction as moderate. Thioguanine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Thioguanine adds marrow suppression, so infection risk may rise.
How serious is the interaction between Thioguanine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and evaluate fever promptly. Reduce the thioguanine dose or delay treatment if significant neutropenia occurs.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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