Drug interactions
Thioguanine + Ublituximab
Severity: Moderate
Thioguanine and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab causes B-cell depletion and thioguanine causes myelosuppression, so the combination may increase susceptibility to infections.
What this interaction means in plain words
Thioguanine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thioguanine belongs to Oncology; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from B-cell depletion and antimetabolite myelosuppression.
What to do
Monitor blood counts and for infection, and consider prophylaxis per local protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioguanine
Other interactions of Ublituximab
Frequently asked questions
Can I take Thioguanine with Ublituximab?
MediHelp rates the interaction as moderate. Thioguanine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab causes B-cell depletion and thioguanine causes myelosuppression, so the combination may increase susceptibility to infections.
How serious is the interaction between Thioguanine and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection, and consider prophylaxis per local protocols.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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