Drug interactions
Thiotepa + Trastuzumab
Severity: Moderate
Thiotepa and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiotepa is a myelosuppressive alkylating agent that can cause profound cytopenias. With trastuzumab, neutropenia and infection risk may be increased.
What this interaction means in plain words
Thiotepa and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thiotepa belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts and for infection. Adjust thiotepa dose for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Thiotepa with Trastuzumab?
MediHelp rates the interaction as moderate. Thiotepa and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiotepa is a myelosuppressive alkylating agent that can cause profound cytopenias. With trastuzumab, neutropenia and infection risk may be increased.
How serious is the interaction between Thiotepa and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection. Adjust thiotepa dose for significant cytopenias.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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