Drug interactions
Thiothixene + Tolterodine
Severity: Moderate
Thiothixene and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use can intensify dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients. Thiothixene also has dopamine-blocking effects that are not offset by tolterodine.
What this interaction means in plain words
Thiothixene and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive peripheral and central anticholinergic effects of the two drugs.
What to do
Monitor for anticholinergic toxicity, especially cognition, bowel function and urinary retention, and avoid the combination in frail elderly or delirium-prone patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Thiothixene with Tolterodine?
MediHelp rates the interaction as moderate. Thiothixene and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can intensify dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients. Thiothixene also has dopamine-blocking effects that are not offset by tolterodine.
How serious is the interaction between Thiothixene and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially cognition, bowel function and urinary retention, and avoid the combination in frail elderly or delirium-prone patients.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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