Drug interactions
Ticarcillin + Tolmetin
Severity: Minor
Ticarcillin and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are highly protein bound and eliminated by renal tubular secretion, so an NSAID may modestly raise penicillin exposure. Clinically significant toxicity is not well documented, and the effect is generally small. Ticarcillin can also impair platelet function at high doses, adding slightly to NSAID bleeding tendency.
What this interaction means in plain words
Ticarcillin and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion, with theoretical protein binding displacement.
What to do
No routine adjustment is needed; watch for bleeding and renal function in high-dose or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Ticarcillin with Tolmetin?
MediHelp rates the interaction as minor. Ticarcillin and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are highly protein bound and eliminated by renal tubular secretion, so an NSAID may modestly raise penicillin exposure. Clinically significant toxicity is not well documented, and the effect is generally small. Ticarcillin can also impair platelet function at high doses, adding slightly to NSAID bleeding tendency.
How serious is the interaction between Ticarcillin and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for bleeding and renal function in high-dose or renally impaired patients.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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