Drug interactions
Timolol + Vilanterol / fluticasone furoate inhaled
Severity: Major
Timolol and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol blocks beta-2 receptors and can oppose vilanterol bronchodilation. It may trigger bronchospasm in people with asthma or COPD, including with eye drops.
What this interaction means in plain words
Timolol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Avoid timolol in these patients and use an alternative glaucoma agent. If a beta-blocker is essential, use a beta-1 selective drug and monitor lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Timolol with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Timolol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol blocks beta-2 receptors and can oppose vilanterol bronchodilation. It may trigger bronchospasm in people with asthma or COPD, including with eye drops.
How serious is the interaction between Timolol and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid timolol in these patients and use an alternative glaucoma agent. If a beta-blocker is essential, use a beta-1 selective drug and monitor lung function.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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