Drug interactions
Timolol + Yohimbe
Severity: Minor
Timolol and Yohimbe: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe is an alpha-2 antagonist that can raise blood pressure and heart rate, while timolol blocks beta-adrenergic effects and may blunt the tachycardia. Blood pressure effects may still be unpredictable, and yohimbe can reduce the antihypertensive efficacy of timolol.
What this interaction means in plain words
Timolol and Yohimbe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism between yohimbine-induced sympathetic stimulation and beta-blockade.
What to do
Discourage yohimbe use in patients treated for hypertension or arrhythmia; monitor blood pressure and heart rate if it is taken.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Timolol with Yohimbe?
MediHelp rates the interaction as minor. Timolol and Yohimbe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbe is an alpha-2 antagonist that can raise blood pressure and heart rate, while timolol blocks beta-adrenergic effects and may blunt the tachycardia. Blood pressure effects may still be unpredictable, and yohimbe can reduce the antihypertensive efficacy of timolol.
How serious is the interaction between Timolol and Yohimbe?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage yohimbe use in patients treated for hypertension or arrhythmia; monitor blood pressure and heart rate if it is taken.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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