Drug interactions
Tobramycin + Typhoid vaccine live
Severity: Moderate
Tobramycin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) relies on viable attenuated bacteria to induce immunity, and antibacterial agents may reduce its viability and response. Systemic tobramycin has little gut exposure, so the effect is probably small, but labeling advises avoiding antibacterials around vaccination.
What this interaction means in plain words
Tobramycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may kill the attenuated live vaccine strain, reducing immunogenicity.
What to do
Postpone oral live typhoid vaccination until antibiotic therapy is completed, typically at least 3 days after the last dose per labeling. Revaccinate if given during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Tobramycin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Tobramycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) relies on viable attenuated bacteria to induce immunity, and antibacterial agents may reduce its viability and response. Systemic tobramycin has little gut exposure, so the effect is probably small, but labeling advises avoiding antibacterials around vaccination.
How serious is the interaction between Tobramycin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone oral live typhoid vaccination until antibiotic therapy is completed, typically at least 3 days after the last dose per labeling. Revaccinate if given during therapy.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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