Drug interactions
Tocilizumab + Typhoid polysaccharide vaccine
Severity: Moderate
Tocilizumab and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab may blunt the antibody response to non-live typhoid polysaccharide vaccine. The vaccine is safe to give, but protection may be reduced.
What this interaction means in plain words
Tocilizumab and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-6 receptor blockade attenuates humoral immune responses.
What to do
Vaccinate at least 2 weeks before travel and ideally before starting tocilizumab; reinforce food and water hygiene.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Tocilizumab with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Tocilizumab and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tocilizumab may blunt the antibody response to non-live typhoid polysaccharide vaccine. The vaccine is safe to give, but protection may be reduced.
How serious is the interaction between Tocilizumab and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before travel and ideally before starting tocilizumab; reinforce food and water hygiene.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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