Drug interactions
Tofacitinib + Trastuzumab
Severity: Moderate
Tofacitinib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tofacitinib is immunosuppressive and trastuzumab is used with chemotherapy that causes neutropenia, so infection risk may be increased. Trastuzumab alone is not strongly immunosuppressive, so the interaction is largely theoretical.
What this interaction means in plain words
Tofacitinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tofacitinib belongs to Musculoskeletal; Trastuzumab belongs to Oncology.
Why it happens
Additive immune and hematologic effects; trastuzumab does not have a direct pharmacokinetic interaction with tofacitinib.
What to do
Monitor blood counts and for signs of infection. Review the need for tofacitinib in patients with active malignancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Tofacitinib with Trastuzumab?
MediHelp rates the interaction as moderate. Tofacitinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tofacitinib is immunosuppressive and trastuzumab is used with chemotherapy that causes neutropenia, so infection risk may be increased. Trastuzumab alone is not strongly immunosuppressive, so the interaction is largely theoretical.
How serious is the interaction between Tofacitinib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection. Review the need for tofacitinib in patients with active malignancy.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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