Drug interactions
Tofacitinib + Vinorelbine
Severity: Major
Tofacitinib and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine commonly causes neutropenia, and tofacitinib adds further immunosuppression. The combination raises the risk of severe infections.
What this interaction means in plain words
Tofacitinib and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tofacitinib belongs to Musculoskeletal; Vinorelbine belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Avoid the combination if possible. If both are required, monitor neutrophil counts and assess promptly for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Vinorelbine
Frequently asked questions
Can I take Tofacitinib with Vinorelbine?
MediHelp rates the interaction as major. Tofacitinib and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinorelbine commonly causes neutropenia, and tofacitinib adds further immunosuppression. The combination raises the risk of severe infections.
How serious is the interaction between Tofacitinib and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are required, monitor neutrophil counts and assess promptly for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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