Drug interactions
Tolmetin + Triamcinolone acetonide injectable
Severity: Moderate
Tolmetin and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a corticosteroid raises the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is greater with systemic exposure, higher doses, prolonged use and older age. A single local injection carries lower risk.
What this interaction means in plain words
Tolmetin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury: NSAID prostaglandin inhibition plus corticosteroid impairment of mucosal defense and healing.
What to do
Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Report black stools or abdominal pain promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Tolmetin with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Tolmetin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a corticosteroid raises the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is greater with systemic exposure, higher doses, prolonged use and older age. A single local injection carries lower risk.
How serious is the interaction between Tolmetin and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Report black stools or abdominal pain promptly.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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