Drug interactions
Tolmetin + Venlafaxine
Severity: Moderate
Tolmetin and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine inhibits serotonin reuptake in platelets, impairing aggregation, and with an NSAID it raises the risk of upper gastrointestinal bleeding. The risk is greater in older patients and those with prior GI bleeding.
What this interaction means in plain words
Tolmetin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolmetin belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function (serotonin depletion plus COX inhibition) combined with NSAID gastric mucosal injury.
What to do
Monitor for GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Limit the NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Tolmetin with Venlafaxine?
MediHelp rates the interaction as moderate. Tolmetin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine inhibits serotonin reuptake in platelets, impairing aggregation, and with an NSAID it raises the risk of upper gastrointestinal bleeding. The risk is greater in older patients and those with prior GI bleeding.
How serious is the interaction between Tolmetin and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Limit the NSAID dose and duration.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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