Drug interactions
Tolterodine + Trifluoperazine
Severity: Moderate
Tolterodine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has some antimuscarinic activity, so combining it with tolterodine can add to dry mouth, constipation, urinary retention and cognitive impairment. Both agents can also prolong the QT interval to a small degree.
What this interaction means in plain words
Tolterodine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects, with possible additive QT prolongation.
What to do
Monitor for anticholinergic adverse effects and consider an ECG in patients with other QT risk factors; use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Tolterodine with Trifluoperazine?
MediHelp rates the interaction as moderate. Tolterodine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has some antimuscarinic activity, so combining it with tolterodine can add to dry mouth, constipation, urinary retention and cognitive impairment. Both agents can also prolong the QT interval to a small degree.
How serious is the interaction between Tolterodine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and consider an ECG in patients with other QT risk factors; use the lowest effective doses.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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