Drug interactions
Tolterodine + Trospium chloride
Severity: Moderate
Tolterodine and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic bladder agents, so taking them together duplicates therapy and increases anticholinergic adverse effects such as dry mouth, constipation, blurred vision and urinary retention. There is no recognised benefit over using a single agent.
What this interaction means in plain words
Tolterodine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism from two drugs of the same class.
What to do
Avoid concurrent use of two antimuscarinics for overactive bladder; optimise the dose of one agent or switch class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Tolterodine with Trospium chloride?
MediHelp rates the interaction as moderate. Tolterodine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic bladder agents, so taking them together duplicates therapy and increases anticholinergic adverse effects such as dry mouth, constipation, blurred vision and urinary retention. There is no recognised benefit over using a single agent.
How serious is the interaction between Tolterodine and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinics for overactive bladder; optimise the dose of one agent or switch class.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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