Drug interactions
Tolterodine + Venlafaxine
Severity: Minor
Tolterodine and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a weak CYP2D6 inhibitor and is expected to have little effect on tolterodine exposure. Any clinical consequence would be limited to mildly increased anticholinergic effects.
What this interaction means in plain words
Tolterodine and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tolterodine belongs to Genitourinary; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6 metabolism of tolterodine.
What to do
No dose adjustment is generally required; monitor for anticholinergic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Tolterodine with Venlafaxine?
MediHelp rates the interaction as minor. Tolterodine and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Venlafaxine is a weak CYP2D6 inhibitor and is expected to have little effect on tolterodine exposure. Any clinical consequence would be limited to mildly increased anticholinergic effects.
How serious is the interaction between Tolterodine and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for anticholinergic adverse effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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