Drug interactions
Tolterodine + Zotepine
Severity: Moderate
Tolterodine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has substantial anticholinergic activity and combined use with tolterodine can add to peripheral and central antimuscarinic effects. Both agents may also prolong the QT interval, and zotepine lowers seizure threshold.
What this interaction means in plain words
Tolterodine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects and possible additive QT prolongation.
What to do
Monitor for constipation, urinary retention and confusion, and obtain an ECG if other QT-prolonging risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Tolterodine with Zotepine?
MediHelp rates the interaction as moderate. Tolterodine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has substantial anticholinergic activity and combined use with tolterodine can add to peripheral and central antimuscarinic effects. Both agents may also prolong the QT interval, and zotepine lowers seizure threshold.
How serious is the interaction between Tolterodine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention and confusion, and obtain an ECG if other QT-prolonging risk factors exist.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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