Drug interactions
Topiramate + Zuranolone
Severity: Moderate
Topiramate and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes dose-related sedation and impaired psychomotor performance, and topiramate adds its own CNS depressant effects. Together they can increase somnolence, confusion and the risk of accidents.
What this interaction means in plain words
Topiramate and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Topiramate belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic synergism).
What to do
Monitor for excessive sedation and cognitive impairment, and consider reducing the zuranolone dose if symptoms occur. Advise patients not to drive for at least 12 hours after zuranolone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Topiramate and Zuranolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Topiramate
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Topiramate with Zuranolone?
MediHelp rates the interaction as moderate. Topiramate and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes dose-related sedation and impaired psychomotor performance, and topiramate adds its own CNS depressant effects. Together they can increase somnolence, confusion and the risk of accidents.
How serious is the interaction between Topiramate and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive impairment, and consider reducing the zuranolone dose if symptoms occur. Advise patients not to drive for at least 12 hours after zuranolone.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
