Drug interactions
Trandolapril + Zotepine
Severity: Moderate
Trandolapril and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-1 adrenergic blocking activity that can lower blood pressure and cause orthostatic hypotension. Combined with an ACE inhibitor, the hypotensive effect is additive and may be pronounced after starting or increasing either drug.
What this interaction means in plain words
Trandolapril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension from ACE inhibition and zotepine alpha-1 adrenergic antagonism.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Begin with low doses and advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Trandolapril with Zotepine?
MediHelp rates the interaction as moderate. Trandolapril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-1 adrenergic blocking activity that can lower blood pressure and cause orthostatic hypotension. Combined with an ACE inhibitor, the hypotensive effect is additive and may be pronounced after starting or increasing either drug.
How serious is the interaction between Trandolapril and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Begin with low doses and advise patients to rise slowly.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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