Drug interactions
Trastuzumab + Trifluridine / tipiracil
Severity: Moderate
Trastuzumab and Trifluridine / tipiracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluridine/tipiracil frequently causes neutropenia and can cause febrile neutropenia. With trastuzumab, neutropenia risk may be higher.
What this interaction means in plain words
Trastuzumab and Trifluridine / tipiracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts before each cycle and for infection. Delay or reduce trifluridine/tipiracil for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Trastuzumab with Trifluridine / tipiracil?
MediHelp rates the interaction as moderate. Trastuzumab and Trifluridine / tipiracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluridine/tipiracil frequently causes neutropenia and can cause febrile neutropenia. With trastuzumab, neutropenia risk may be higher.
How serious is the interaction between Trastuzumab and Trifluridine / tipiracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each cycle and for infection. Delay or reduce trifluridine/tipiracil for significant neutropenia.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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