Drug interactions
Tretinoin + Trifluoperazine
Severity: Moderate
Tretinoin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as trifluoperazine can cause photosensitivity, and tretinoin increases skin susceptibility to ultraviolet light. Combined use may increase sunburn or phototoxic reactions.
What this interaction means in plain words
Tretinoin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects of a retinoid and a phenothiazine.
What to do
Counsel on sunscreen, protective clothing and sun avoidance. Reduce or hold tretinoin if skin irritation or phototoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Tretinoin with Trifluoperazine?
MediHelp rates the interaction as moderate. Tretinoin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as trifluoperazine can cause photosensitivity, and tretinoin increases skin susceptibility to ultraviolet light. Combined use may increase sunburn or phototoxic reactions.
How serious is the interaction between Tretinoin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sunscreen, protective clothing and sun avoidance. Reduce or hold tretinoin if skin irritation or phototoxicity develops.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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