Drug interactions
Typhoid vaccine live + Ustekinumab
Severity: Contraindicated
Typhoid vaccine live and Ustekinumab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated typhoid vaccine could cause disseminated infection in patients receiving an immunosuppressive biologic such as ustekinumab. Immune response to the vaccine may also be reduced.
What this interaction means in plain words
Typhoid vaccine live and Ustekinumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression from interleukin-12/23 inhibition impairs control of replicating attenuated vaccine organisms and may reduce vaccine immunogenicity.
What to do
Avoid live typhoid vaccine during ustekinumab therapy; use the inactivated injectable Vi polysaccharide vaccine instead. If a live vaccine is needed, give it before starting therapy, following the labeled interval.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
- Anti-thymocyte + Ustekinumab Major
Frequently asked questions
Can I take Typhoid vaccine live with Ustekinumab?
MediHelp rates the interaction as contraindicated. Typhoid vaccine live and Ustekinumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The oral live attenuated typhoid vaccine could cause disseminated infection in patients receiving an immunosuppressive biologic such as ustekinumab. Immune response to the vaccine may also be reduced.
How serious is the interaction between Typhoid vaccine live and Ustekinumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live typhoid vaccine during ustekinumab therapy; use the inactivated injectable Vi polysaccharide vaccine instead. If a live vaccine is needed, give it before starting therapy, following the labeled interval.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Adalimumab, Adenovirus types 4 and 7 live. The full list is on the Ustekinumab page.
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