Drug interactions
Valsartan + Xipamide
Severity: Moderate
Valsartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide, a thiazide-like diuretic, adds to the blood pressure lowering of valsartan and may cause hypotension, especially with volume depletion. Electrolyte disturbances and renal function changes can also occur.
What this interaction means in plain words
Valsartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: diuretic-induced natriuresis and volume reduction together with angiotensin II receptor blockade.
What to do
Monitor blood pressure, electrolytes and renal function after starting or changing doses. Consider a lower starting dose in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Valsartan with Xipamide?
MediHelp rates the interaction as moderate. Valsartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide, a thiazide-like diuretic, adds to the blood pressure lowering of valsartan and may cause hypotension, especially with volume depletion. Electrolyte disturbances and renal function changes can also occur.
How serious is the interaction between Valsartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and renal function after starting or changing doses. Consider a lower starting dose in volume-depleted patients.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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