Drug interactions
Zolpidem + Zuranolone
Severity: Moderate
Zolpidem and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and driving impairment, and zolpidem may add to these CNS depressant effects, increasing psychomotor impairment.
What this interaction means in plain words
Zolpidem and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Zolpidem belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A receptor modulation.
What to do
Avoid zolpidem during zuranolone therapy if possible; otherwise reduce doses and counsel the patient not to drive or operate machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Zolpidem with Zuranolone?
MediHelp rates the interaction as moderate. Zolpidem and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and driving impairment, and zolpidem may add to these CNS depressant effects, increasing psychomotor impairment.
How serious is the interaction between Zolpidem and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid zolpidem during zuranolone therapy if possible; otherwise reduce doses and counsel the patient not to drive or operate machinery.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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