مرجع دارویی
Oliceridine
Oliceridine is a medicine in the class musculoskeletal. It is used for pain management.
- گروه دارویی: Musculoskeletal
- موارد مصرف: pain management
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
نکات کلیدی
- گروه دارویی
- Musculoskeletal
- شکل‌های دارویی رایج
- آمپول
- تداخل‌های شناخته‌شده
- 200 (منع مصرف: 1 · شدید: 98 · متوسط: 78 · جزئی: 23)
- نام‌های تجاری
- 1
- کشورها و بازارها
- 1
موارد مصرف
نحوه اثر
Oliceridine is a full opioid agonist, relatively selective for the mu-opioid receptor; its principal therapeutic action is analgesia, with no ceiling effect to analgesia.
دوز معمول بزرگسالان (خلاصه برچسب)
Acute pain severe enough to require an IV opioid: initial dose 1.5 mg IV given by a healthcare provider; supplemental doses of 0.75 mg beginning 1 hour after the initial dose and hourly thereafter as needed; single doses greater than 3 mg not to be given; maximum cumulative daily dose 27 mg.
بارداری و شیردهی
- بارداری
- Unsafe Prolonged use in pregnancy may cause neonatal opioid withdrawal syndrome; no human data on birth defects. Animal studies showed reduced live litter size and increased pup mortality. Not recommended during and immediately before labor.
- شیردهی
- Unknown It is not known whether oliceridine is in human milk; weigh the benefits of breastfeeding against the mother's need. Monitor exposed infants for excess sedation and respiratory depression.
عوارض جانبی گزارش‌شده
- Nausea
- Vomiting
- Dizziness
- Headache
- Constipation
- Pruritus
هشدارهای جعبه سیاه
- Exposes users to risks of opioid addiction, abuse and misuse, which can lead to overdose and death; assess risk before prescribing and reassess regularly. Serious, life-threatening or fatal respiratory depression may occur, especially during initiation or after a dosage increase. Concomitant use with benzodiazepines or other CNS depressants, including alcohol, may cause profound sedation, respiratory depression, coma and death; reserve for patients with inadequate alternatives. Prolonged use in pregnancy can cause neonatal opioid withdrawal syndrome, which may be life-threatening.
موارد منع مصرف
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or without resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
چه کسانی باید احتیاط کنند
- QTc prolongation risk with cumulative daily doses above 27 mg; do not exceed 27 mg.
- Increased oliceridine exposure with decreased CYP2D6 function or with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can prolong adverse reactions and worsen respiratory depression.
- Opioid-induced hyperalgesia and allodynia may occur; consider dose reduction or opioid rotation if suspected.
بارداری یا شیردهی، بیماری کلیه یا کبد، آلرژی‌ها و هر داروی یا مکمل دیگری را که مصرف می‌کنید به داروساز یا پزشک خود اطلاع دهید.
مهم‌ترین تداخلات (200)
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
- Aripiprazole + Oliceridine Major
- Asenapine + Oliceridine Major
- Baclofen + Oliceridine Major
- Brexpiprazole + Oliceridine Major
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا تک‌نگاری کامل Oliceridine را ببینید: دوزها، بارداری و شیردهی، عوارض جانبی، هشدارها و همه تداخل‌ها.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
داروهای دیگر همین گروه
پرسش‌های متداول
What is Oliceridine used for?
Oliceridine is a medicine in the class musculoskeletal. It is used for Pain management.
What side effects have been reported with Oliceridine?
Nausea, Vomiting, Dizziness, Headache, Constipation, Pruritus. Serious warning: Exposes users to risks of opioid addiction, abuse and misuse, which can lead to overdose and death; assess risk before prescribing and reassess regularly.
Can Oliceridine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Prolonged use in pregnancy may cause neonatal opioid withdrawal syndrome; no human data on birth defects. Animal studies showed reduced live litter size and increased pup mortality. Not recommended during and immediately before labor. Breastfeeding: Unknown. It is not known whether oliceridine is in human milk; weigh the benefits of breastfeeding against the mother's need. Monitor exposed infants for excess sedation and respiratory depression.
What does Oliceridine interact with?
MediHelp lists 200 known interactions for Oliceridine. Contraindicated: 1 · Major: 98 · Moderate: 78 · Minor: 23. The most serious include Isocarboxazid, Alprazolam, Amiodarone.
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