تداخل‌های دارویی
Amitriptyline + Oliceridine
شدت: شدید
Amitriptyline and Oliceridine: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both drugs depress the CNS, so combined use can cause profound sedation and respiratory depression. Amitriptyline's anticholinergic effects may add to opioid-induced constipation and urinary retention, and serotonergic effects pose a small serotonin syndrome risk.
معنای این تداخل به زبان ساده
Amitriptyline and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
چرا رخ می‌دهد
Additive CNS and respiratory depression, with additive antimuscarinic effects on gut and bladder and some serotonergic activity.
اقدام لازم
Use the lowest effective oliceridine dose for the shortest time and monitor for sedation and respiratory depression. Monitor bowel and bladder function and watch for serotonin toxicity.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Oliceridine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Amitriptyline
- Amitriptyline + Isocarboxazid منع مصرف
- Amitriptyline + Methylene blue منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amitriptyline + Pimozide منع مصرف
- Amitriptyline + Procarbazine منع مصرف
- Amitriptyline + Safinamide منع مصرف
تداخلات دیگر Oliceridine
پرسش‌های متداول
Can I take Amitriptyline with Oliceridine?
MediHelp rates the interaction as major. Amitriptyline and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress the CNS, so combined use can cause profound sedation and respiratory depression. Amitriptyline's anticholinergic effects may add to opioid-induced constipation and urinary retention, and serotonergic effects pose a small serotonin syndrome risk.
How serious is the interaction between Amitriptyline and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose for the shortest time and monitor for sedation and respiratory depression. Monitor bowel and bladder function and watch for serotonin toxicity.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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