مرجع دارویی
Thalidomide
Thalidomide is a medicine in the class miscellaneous. It is used for multiple myeloma.
- گروه دارویی: Miscellaneous
- موارد مصرف: multiple myeloma
آخرین به‌روزرسانی منابع: US FDA label، EMA SmPC
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
نکات کلیدی
- گروه دارویی
- Miscellaneous
- کد ATC
- L04AX02
- شکل‌های دارویی رایج
- کپسول
- تداخل‌های شناخته‌شده
- 41 (شدید: 9 · متوسط: 29 · جزئی: 3)
- نام‌های تجاری
- 3
- کشورها و بازارها
- 2
موارد مصرف
نحوه اثر
Mechanism not fully understood. Acts through cereblon, a component of a cullin ring E3 ubiquitin ligase complex; has immunomodulatory, anti-inflammatory and antiangiogenic properties.
دوز معمول بزرگسالان (خلاصه برچسب)
Newly diagnosed multiple myeloma (with dexamethasone): 200 mg orally once daily in 28-day cycles, with water, preferably at bedtime and at least 1 hour after the evening meal; dexamethasone 40 mg daily on days 1-4, 9-12 and 17-20 every 28 days
بارداری و شیردهی
- بارداری
- Unsafe Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms.
- شیردهی
- Unsafe No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.
عوارض جانبی گزارش‌شده
- Fatigue
- Hypocalcemia
- Edema
- Constipation
- Sensory neuropathy
- Dyspnea
هشدارهای جعبه سیاه
- Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule. Must never be used by females who are or could become pregnant. Exclude pregnancy before treatment and use two reliable contraception methods. Available only through the THALOMID REMS program.
موارد منع مصرف
- Pregnancy
- Demonstrated hypersensitivity to the drug or its components
چه کسانی باید احتیاط کنند
- Venous and arterial thromboembolism, including ischemic heart disease, MI and stroke, with dexamethasone
- Increased mortality when pembrolizumab is added to a thalidomide analogue plus dexamethasone in MM; not recommended outside controlled trials
- Frequent drowsiness and somnolence; avoid hazardous tasks and other sedating drugs
بارداری یا شیردهی، بیماری کلیه یا کبد، آلرژی‌ها و هر داروی یا مکمل دیگری را که مصرف می‌کنید به داروساز یا پزشک خود اطلاع دهید.
مهم‌ترین تداخلات (41)
- Bortezomib + Thalidomide Major
- Carbamazepine + Thalidomide Major
- Griseofulvin + Thalidomide Major
- Modafinil + Thalidomide Major
- Nivolumab + Thalidomide Major
- Phenytoin + Thalidomide Major
- Rifabutin + Thalidomide Major
- Rifampicin + Thalidomide Major
- Thalidomide + Vincristine Major
- Amiodarone + Thalidomide Moderate
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا تک‌نگاری کامل Thalidomide را ببینید: دوزها، بارداری و شیردهی، عوارض جانبی، هشدارها و همه تداخل‌ها.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
داروهای دیگر همین گروه
پرسش‌های متداول
What is Thalidomide used for?
Thalidomide is a medicine in the class miscellaneous. It is used for Multiple myeloma.
What side effects have been reported with Thalidomide?
Fatigue, Hypocalcemia, Edema, Constipation, Sensory neuropathy, Dyspnea. Serious warning: Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule.
Can Thalidomide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms. Breastfeeding: Unsafe. No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.
What does Thalidomide interact with?
MediHelp lists 41 known interactions for Thalidomide. Major: 9 · Moderate: 29 · Minor: 3. The most serious include Bortezomib, Carbamazepine, Griseofulvin.
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