Venetoclax

موارد مصرف

• Chronic lymphocytic leukemia
• Leukemia

نحوه اثر

دوز معمول بزرگسالان (خلاصه برچسب)

خلاصه برچسب فقط برای نخستین سطر دوزبندی؛ بخش‌های کامل دوزبندی در اپلیکیشن موجود است.

بارداری و شیردهی

بارداری

Unsafe May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose.

شیردهی

Unsafe No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.

عوارض جانبی گزارش‌شده

• Neutropenia
• Thrombocytopenia
• Anemia
• Diarrhea
• Nausea
• Fatigue

موارد منع مصرف

• Concomitant use with strong CYP3A inhibitors at initiation and during the ramp-up phase in patients with CLL/SLL, due to increased TLS risk

چه کسانی باید احتیاط کنند

• Tumor lysis syndrome, including fatal events and renal failure requiring dialysis; assess risk, give hydration and anti-hyperuricemics, and monitor blood chemistries
• Neutropenia: monitor complete blood counts throughout treatment and consider supportive measures
• Fatal and serious infections such as pneumonia and sepsis; withhold for Grade 3 and 4 infection until resolution

بارداری یا شیردهی، بیماری کلیه یا کبد، آلرژی‌ها و هر داروی یا مکمل دیگری را که مصرف می‌کنید به داروساز یا پزشک خود اطلاع دهید.

مهم‌ترین تداخلات (68)

• Clarithromycin + Venetoclax Contraindicated
• Itraconazole + Venetoclax Contraindicated
• Ketoconazole + Venetoclax Contraindicated
• Posaconazole + Venetoclax Contraindicated
• Venetoclax + Voriconazole Contraindicated
• Amiodarone + Venetoclax Major
• Apalutamide + Venetoclax Major
• Aprepitant + Venetoclax Major
• Armodafinil + Venetoclax Major
• Bosentan + Venetoclax Major

All 68 interactions, with severity and what to do

پرسش‌های متداول