تداخل‌های دارویی
Clarithromycin + Venetoclax
شدت: منع مصرف
Clarithromycin and Venetoclax: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Clarithromycin increases venetoclax exposure through CYP3A4 and P-glycoprotein inhibition. During initiation and dose ramp-up this increases the risk of tumor lysis syndrome and neutropenia. After ramp-up, strong inhibitors require a major venetoclax dose reduction.
معنای این تداخل به زبان ساده
Clarithromycin and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Venetoclax belongs to Miscellaneous.
چرا رخ می‌دهد
Inhibition of CYP3A4 and P-glycoprotein reduces venetoclax clearance and increases absorption.
اقدام لازم
Do not use during venetoclax initiation or ramp-up; use an alternative antibiotic. After ramp-up, if unavoidable, reduce the venetoclax dose by at least 75% and monitor for toxicity and blood counts.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Venetoclax، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Clarithromycin
- Astemizole + Clarithromycin منع مصرف
- Avanafil + Clarithromycin منع مصرف
- Cisapride + Clarithromycin منع مصرف
- Clarithromycin + Colchicine منع مصرف
- Clarithromycin + Conivaptan منع مصرف
- Clarithromycin + Dihydroergotamine منع مصرف
تداخلات دیگر Venetoclax
- Itraconazole + Venetoclax منع مصرف
- Ketoconazole + Venetoclax منع مصرف
- Posaconazole + Venetoclax منع مصرف
- Venetoclax + Voriconazole منع مصرف
- Amiodarone + Venetoclax شدید
- Apalutamide + Venetoclax شدید
پرسش‌های متداول
Can I take Clarithromycin with Venetoclax?
MediHelp rates the interaction as contraindicated. Clarithromycin and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases venetoclax exposure through CYP3A4 and P-glycoprotein inhibition. During initiation and dose ramp-up this increases the risk of tumor lysis syndrome and neutropenia. After ramp-up, strong inhibitors require a major venetoclax dose reduction.
How serious is the interaction between Clarithromycin and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation or ramp-up; use an alternative antibiotic. After ramp-up, if unavoidable, reduce the venetoclax dose by at least 75% and monitor for toxicity and blood counts.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
