تداخل‌های دارویی
Alfentanil + Diphenoxylate-atropine
شدت: شدید
Alfentanil and Diphenoxylate-atropine: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Diphenoxylate is an opioid, and together with alfentanil it can increase sedation and respiratory depression. Risk is higher at high diphenoxylate doses or in children and those with hepatic impairment.
معنای این تداخل به زبان ساده
Alfentanil and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive opioid-mediated CNS and respiratory depression.
اقدام لازم
Monitor respiratory rate and sedation level during alfentanil use and reduce the alfentanil dose as needed. Hold diphenoxylate-atropine where possible around procedures.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Alfentanil و Diphenoxylate-atropine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Diphenoxylate-atropine
پرسش‌های متداول
Can I take Alfentanil with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Alfentanil and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diphenoxylate is an opioid, and together with alfentanil it can increase sedation and respiratory depression. Risk is higher at high diphenoxylate doses or in children and those with hepatic impairment.
How serious is the interaction between Alfentanil and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation level during alfentanil use and reduce the alfentanil dose as needed. Hold diphenoxylate-atropine where possible around procedures.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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