تداخل‌های دارویی
Diphenoxylate-atropine + Isocarboxazid
شدت: منع مصرف
Diphenoxylate-atropine and Isocarboxazid: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Diphenoxylate is structurally related to meperidine, and MAO inhibitors can cause severe reactions with such opioids. Hypertensive crisis, hyperpyrexia, hypotension, somnolence or death may occur. Labeling advises against use of diphenoxylate with MAO inhibitors.
معنای این تداخل به زبان ساده
Diphenoxylate-atropine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Isocarboxazid belongs to Central Nervous System.
چرا رخ می‌دهد
MAO inhibition may potentiate diphenoxylate through a meperidine-like interaction; the exact mechanism is not fully established.
اقدام لازم
Do not use together or within 14 days of stopping the MAO inhibitor. Use a non-opioid antidiarrheal alternative.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Diphenoxylate-atropine و Isocarboxazid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Diphenoxylate-atropine
تداخلات دیگر Isocarboxazid
- 5-HTP + Isocarboxazid منع مصرف
- Amitriptyline + Isocarboxazid منع مصرف
- Amobarbital + Isocarboxazid منع مصرف
- Amoxapine + Isocarboxazid منع مصرف
- Apraclonidine + Isocarboxazid منع مصرف
- Atomoxetine + Isocarboxazid منع مصرف
پرسش‌های متداول
Can I take Diphenoxylate-atropine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Diphenoxylate-atropine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diphenoxylate is structurally related to meperidine, and MAO inhibitors can cause severe reactions with such opioids. Hypertensive crisis, hyperpyrexia, hypotension, somnolence or death may occur. Labeling advises against use of diphenoxylate with MAO inhibitors.
How serious is the interaction between Diphenoxylate-atropine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAO inhibitor. Use a non-opioid antidiarrheal alternative.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Phenelzine, Tranylcypromine, Alfentanil. The full list is on the Diphenoxylate-atropine page.
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