تداخل‌های دارویی
Aliskiren + Losartan
شدت: منع مصرف
Aliskiren and Losartan: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining an angiotensin receptor blocker with aliskiren produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment, including acute kidney injury, without added outcome benefit. The combination is contraindicated in patients with diabetes and should be avoided in renal impairment.
معنای این تداخل به زبان ساده
Aliskiren and Losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Aliskiren belongs to Cardiovascular; Losartan belongs to Cardiovascular.
چرا رخ می‌دهد
Additive pharmacodynamic blockade of the renin-angiotensin-aldosterone system at two different points.
اقدام لازم
Do not co-prescribe in patients with diabetes or with GFR below 60 mL/min; avoid in others where possible. If ever used, monitor blood pressure, potassium and creatinine closely.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Aliskiren و Losartan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Losartan
تداخلات دیگر Aliskiren
پرسش‌های متداول
Can I take Aliskiren with Losartan?
MediHelp rates the interaction as contraindicated. Aliskiren and Losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an angiotensin receptor blocker with aliskiren produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment, including acute kidney injury, without added outcome benefit. The combination is contraindicated in patients with diabetes and should be avoided in renal impairment.
How serious is the interaction between Aliskiren and Losartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe in patients with diabetes or with GFR below 60 mL/min; avoid in others where possible. If ever used, monitor blood pressure, potassium and creatinine closely.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Sparsentan, Amifostine, Amiloride. The full list is on the Losartan page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
