تداخل‌های دارویی
Amifostine + Losartan
شدت: شدید
Amifostine and Losartan: major interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Amifostine commonly causes hypotension, and antihypertensives such as losartan can worsen the fall in blood pressure. At chemotherapeutic doses of amifostine, severe hypotension is a concern.
معنای این تداخل به زبان ساده
Amifostine and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amifostine belongs to Miscellaneous; Losartan belongs to Cardiovascular.
چرا رخ می‌دهد
Additive pharmacodynamic hypotensive effects of the two drugs.
اقدام لازم
For chemotherapeutic amifostine doses, withhold losartan for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely and ensure hydration.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amifostine و Losartan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Losartan
تداخلات دیگر Amifostine
پرسش‌های متداول
Can I take Amifostine with Losartan?
MediHelp rates the interaction as major. Amifostine and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amifostine commonly causes hypotension, and antihypertensives such as losartan can worsen the fall in blood pressure. At chemotherapeutic doses of amifostine, severe hypotension is a concern.
How serious is the interaction between Amifostine and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For chemotherapeutic amifostine doses, withhold losartan for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely and ensure hydration.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amiloride. The full list is on the Losartan page.
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