تداخل‌های دارویی
Alteplase + Ticagrelor
شدت: شدید
Alteplase and Ticagrelor: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ticagrelor is a potent platelet inhibitor, and giving a thrombolytic on top of it increases the likelihood of major bleeding, including intracranial hemorrhage. The combination is used in some acute coronary settings but with clear added risk.
معنای این تداخل به زبان ساده
Alteplase and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alteplase belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
چرا رخ می‌دهد
Additive pharmacodynamic effect: reversible P2Y12 receptor blockade by ticagrelor combined with plasmin-mediated clot lysis by alteplase.
اقدام لازم
Confirm that thrombolysis is clearly indicated and monitor closely for bleeding, including neurological changes; avoid invasive procedures and arterial punctures where possible.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Alteplase و Ticagrelor، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Alteplase
- Alteplase + Defibrotide منع مصرف
- Alteplase + Reteplase منع مصرف
- Alteplase + Tenecteplase منع مصرف
- Acetylsalicylic acid + Alteplase شدید
- Alteplase + Apixaban شدید
- Alteplase + Argatroban شدید
تداخلات دیگر Ticagrelor
- Itraconazole + Ticagrelor منع مصرف
- Ketoconazole + Ticagrelor منع مصرف
- Levoketoconazole + Ticagrelor منع مصرف
- Abciximab + Ticagrelor شدید
- Abrocitinib + Ticagrelor شدید
- Acalabrutinib + Ticagrelor شدید
پرسش‌های متداول
Can I take Alteplase with Ticagrelor?
MediHelp rates the interaction as major. Alteplase and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticagrelor is a potent platelet inhibitor, and giving a thrombolytic on top of it increases the likelihood of major bleeding, including intracranial hemorrhage. The combination is used in some acute coronary settings but with clear added risk.
How serious is the interaction between Alteplase and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm that thrombolysis is clearly indicated and monitor closely for bleeding, including neurological changes; avoid invasive procedures and arterial punctures where possible.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
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