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تداخل‌های دارویی

Aluminum hydroxide + Rilpivirine

شدت: شدید

Aluminum hydroxide and Rilpivirine: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.

معنای این تداخل به زبان ساده

Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Aluminum hydroxide belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.

سطح شواهد: High

چرا رخ می‌دهد

Elevated gastric pH reduces rilpivirine solubility and oral absorption.

اقدام لازم

Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Aluminum hydroxide و Rilpivirine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Aluminum hydroxide with Rilpivirine?

MediHelp rates the interaction as major. Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.

How serious is the interaction between Aluminum hydroxide and Rilpivirine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.

What other medicines interact with Aluminum hydroxide?

MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.

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