تداخل‌های دارویی
Amikacin + Cefazolin
شدت: متوسط
Amikacin and Cefazolin: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.
معنای این تداخل به زبان ساده
Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefazolin belongs to Anti Bacterial.
چرا رخ می‌دهد
Possible additive renal tubular injury; aminoglycoside toxicity is the dominant contributor.
اقدام لازم
Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amikacin و Cefazolin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cefazolin
تداخلات دیگر Amikacin
پرسش‌های متداول
Can I take Amikacin with Cefazolin?
MediHelp rates the interaction as moderate. Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.
How serious is the interaction between Amikacin and Cefazolin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Bcg vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefazolin page.
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